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Soft Tissue Trauma

Hand soft tissue trauma: assessment, infection risk, and management principles for crush, injection, and compartment syndrome injuries.

Overview

Management of major soft-tissue injuries associated with skeletal fractures requires a planned approach grounded in broad training rather than limited past experience [1]. Appropriate management of the soft-tissue envelope is essential for a good outcome, necessitating that orthopaedic surgeons adhere to strict principles for decision-making and outcome prediction [3]. Open fractures represent serious injuries demanding prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. Prevention remains the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2].

Treatment goals for hand fractures include restoration of length, alignment, and articular congruity, alongside stabilization and soft tissue repair [13]. For open extensor tendon injuries, knowledge of modern repair techniques and rehabilitation protocols may improve patient outcomes [23]. In Zone 2 flexor tendon injuries, the time elapsed between injury and surgery is not an important risk factor for a good outcome; results depend on proper surgical methods, surgeon experience, and early mobilization [14]. Structural repair in human and other mammalian bite injuries of the hand is performed as indicated by the severity and contamination of the injury, and wounds may require delayed closure [61].

Individualized design of thoracodorsal artery perforator chimeric flaps provides flexible coverage for complex soft tissue defects with limited donor site morbidity [15]. The technique of two simultaneous pedicled flaps is a simple and successful alternative to free tissue transfer for coverage of complex soft tissue defects in the hand and forearm, particularly in critically ill, multi-extremity injured patients where free tissue transfer is not indicated [31]. There is insufficient evidence to determine the best splint type or specific indications for surgery in mallet finger injuries [24], and no long-term studies clarify the natural history or high-quality trials addressing surgical indications and outcomes for rheumatoid nodules [59].

Anatomy & Pathophysiology

Treatment goals for hand fractures prioritize the restoration of length, alignment, and articular congruity alongside stabilization and soft tissue repair [13]. Accurate diagnosis and management of hand and carpal fractures and dislocations rely on a thorough physical examination and appropriate imaging to limit joint stiffness while preserving mobility and function [17]. Current evidence regarding the diagnosis of hand compartment syndrome is derived mostly from case reports and small case series with varying etiology, lacking a consensus reference standard or reliable diagnostic criteria [18].

Hand trauma, particularly surgical trauma and repetitive mechanical stress, is associated with the onset of Dupuytren's disease [43]. Closed degloving of the thumb represents a rare condition caused by crushing and elongation forces that detach soft tissues without skin disruption [47]. Regarding protective equipment, common wrist guard design provides limited impact force attenuation, whereas damped pneumatic springs provide substantially enhanced shock-absorbing functions [51].

Classification

General Principles: Management of major and extensive soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training and knowledge rather than limited past experiences [1]. Appropriate management of the soft-tissue envelope is essential to a good outcome in high-energy extremity trauma [3], necessitating that orthopaedic surgeons adhere to strict principles to ensure appropriate decision-making and accurate prediction of outcome [3]. Open fractures are serious injuries requiring prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2].

Acute Compartment Syndrome: Acute compartment syndrome is a clinical emergency requiring vigilance, prompt diagnosis, and treatment [8]. Risk factors for acute compartment syndrome include high-energy injuries, specific fracture patterns, and younger age [8]. Rare causes such as soft tissue sarcoma must be considered in cases of compartment syndrome without clear trauma [5].

Burns and Frostbite: Classification, pathophysiology, and management of burns and frostbite include early splinting in the intrinsic plus position, timely debridement and coverage, and specific treatments like tissue plasminogen activator for frostbite to reduce amputation rates [49].

Tendon and Perforator Injuries: Tearing types of injury, such as those caused by saws, led to poorer outcomes for Zone II flexor tendon injuries compared with sharp injuries at an average follow-up of 4 years [60]. The location of the perforator used for reconstruction of digit soft tissue defects with the fourth common digital artery perforator flap differs from previous descriptions but is routinely and reliably located [64].

Other Considerations: A clear understanding of acetabular osseous anatomy and surrounding soft tissues is essential for evaluation and management of acetabular fractures [6]. Evaluation of coxa vara should include a search for family history, trauma, infection, and associated skeletal abnormalities to classify the condition and select optimal treatment [12]. The COVID-19 pandemic and consequent restrictions of activity resulted in a decrease in overall hand trauma presentations, particularly elective cases, and alterations in injury type and mechanism [7]. Pelnac® artificial dermis assisted by vacuum sealing drainage can be considered a viable alternative for addressing severe avulsion injuries of the fingers or complex wound conditions [28]. Management strategies for xylazine-induced soft-tissue necrosis should be based on the depth of tissue involvement, with amputation often necessary when all tissues in the extremity are involved [63].

Clinical Presentation

Management of major soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training rather than limited past experience [1]. Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury [2]. Appropriate management of the soft-tissue envelope is essential for a good outcome in high-energy extremity trauma [3]. Open fractures are serious injuries requiring prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4].

Acute compartment syndrome is a clinical emergency requiring vigilance, prompt diagnosis, and treatment [8]. Risk factors include high-energy injuries, specific fracture patterns, and younger age [8]. Current diagnostic methods show discrepancies [8], and there is a lack of a consensus reference standard or reliable diagnostic criteria for hand compartment syndrome [18]. Diagnosis is based mostly on case reports and small case series with varying etiology [18]. Crush injury, prolonged decubitus, and infection are the most common causes of acute hand compartment syndrome [38]. A neoplasm should be considered in the differential diagnosis of compartment syndrome, as a soft-tissue sarcoma can cause necrosis and edema leading to acute compartment syndrome [36]. Rare causes such as soft tissue sarcoma should be considered in cases of compartment syndrome without clear trauma [5].

Evaluation for coxa vara should include a search for family history, trauma, infection, and associated skeletal abnormalities [12]. A clear understanding of acetabular osseous anatomy and surrounding soft tissues is essential for evaluation and management of acetabular fractures [6]. Early diagnosis and surgery are critical for treating intramuscular epithelioid sarcoma presenting as extrinsic flexor tightness in the forearm [19]. Any soft-tissue swelling suspected of malignancy is best referred directly to a sarcoma centre due to the complexity of treatment [10].

When signs of rapidly progressive soft-tissue infection develop in a patient exposed to specific environments, Aeromonas hydrophila should be considered as a causative pathogen [11]. The key to effective treatment of necrotizing fasciitis is prompt diagnosis and immediate and thorough debridement of infected necrotic tissue [9]. The unusual presentation of sequential traumatic bilateral extensor pollicis brevis rupture highlights the need to consider this injury when examining the post-traumatic hand [16]. Samurai sword assaults can cause hand injuries with devastating loss of function [20].

The COVID-19 pandemic and consequent restrictions of activity resulted in a decrease in overall hand trauma presentations, particularly elective cases, and alterations in injury type and mechanism [7]. Individuals presenting with self-inflicted gunshot wounds to the hand are more likely to be older [34], require multiple operations [34], develop infections [34], and present with acute carpal tunnel syndrome requiring urgent surgical decompression [34].

Investigations

Plain radiography: Essential for initial evaluation of hand and carpal fractures, dislocations, and pediatric phalangeal lesions such as bizarre parosteal osteochondromatous proliferation (Nora lesion), though diagnosis can be challenging due to variable presenting symptoms and radiographic findings [17, 66]. Augmenting plain radiographs with additional modalities like ultrasound or dark-field imaging may aid in diagnosing septic arthritis of the proximal interphalangeal joint following rattlesnake bites [53].

MRI: The imaging modality of choice for the majority of soft-tissue tumors and is critical for identifying sarcomas prior to unplanned resection [50]. It effectively identifies subcutaneous grease following high-pressure injection injuries, aiding in diagnosis and management [70]. Magnetic resonance imaging further indicates that the donor site after autologous osteochondral mosaicplasty for cartilaginous lesions of the elbow joint is resurfaced with fibrous tissue [67].

Arthrography: Recommended to assist in deciding whether to proceed with surgical or conservative treatment for soft tissue injuries to the dorsum of the metacarpophalangeal joint [68].

Other Considerations: Management of major and extensive soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training and knowledge rather than limited past experiences [1]. Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2]. Appropriate management of the soft-tissue envelope is essential for a good outcome, requiring orthopaedic surgeons to adhere to strict principles for decision making and outcome prediction [3]. Open fractures require prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. Acute compartment syndrome is a clinical emergency requiring vigilance, prompt diagnosis, and treatment, with risk factors including high-energy injuries, specific fracture patterns, and younger age [8]. Current diagnostic methods for acute compartment syndrome show discrepancies [8]. Rare causes such as soft tissue sarcoma should be considered in cases of compartment syndrome without clear trauma [5]. Any soft-tissue swelling suspected of malignancy is best referred directly to a sarcoma centre due to the complexity of treatment [10]. A clear understanding of acetabular osseous anatomy and surrounding soft tissues is essential for evaluation and management [6]. The unusual presentation of sequential traumatic bilateral extensor pollicis brevis rupture highlights the need to consider this injury when examining the post-traumatic hand [16]. Early diagnosis and surgery are critical for treating intramuscular epithelioid sarcoma presenting as extrinsic flexor tightness in the forearm [19]. Minimal, accurate débridement and decompression with early stability are crucial in the early management of ballistic hand trauma [29].

Treatment

Management of major soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training and knowledge rather than limited past experiences [1]. Appropriate management of the soft-tissue envelope is essential to a good outcome, requiring orthopaedic surgeons to adhere to strict principles of soft-tissue management for accurate decision making and outcome prediction [3]. Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2]. Any soft-tissue swelling suspected of malignancy is best referred directly to a sarcoma centre due to the complexity of treatment [10].

Non-Operative

Conservative management is the predominant strategy for Morel-Lavallée lesions in the pediatric population, yielding good functional outcomes [22]. While most patients with lateral epicondylitis respond to non-operative management, a subset requires operative intervention [26]. Conservative management of tendinous mallet finger injuries neglected for 2 to 4 weeks can be treated as well as those presenting within the first 2 weeks of injury, with low long-term complication rates [44]. There is insufficient evidence to determine the best splint type or specific indications for surgery in mallet finger injuries [24].

Operative

Indications: Open fractures require prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. The key to effective treatment of necrotizing fasciitis is prompt diagnosis and immediate and thorough debridement of infected necrotic tissue [9]. Aeromonas hydrophila should be considered as a causative pathogen when signs of rapidly progressive soft-tissue infection develop in relevant patients [11]. Early treatment with debridement and stabilization is recommended for ballistic fractures of the hand and wrist, with primary bone grafting considered due to lack of follow-up and patient noncompliance [57]. Minimal, accurate débridement and decompression with early stability are crucial in the early management of ballistic hand trauma [29]. The lowest rate of sequelae in neonatal limb compartment syndrome was observed when decompression was performed within the first 24 hours, despite nonsurgical management and late fasciotomy (> 24 hours) being the most described treatments [42]. Improved survival rates on the battlefield have resulted in new challenges in the care of U.S. military personnel, necessitating the application of new technology and treatment alternatives [41].

Surgical Approach / Technique: Treatment goals for hand fractures include restoration of length, alignment, and articular congruity, along with stabilization and soft tissue repair [13]. Early debridement, antibiotic treatment, reconstruction, and rehabilitation offer patients the best chance for full functional recovery in gunshot wounds to the hand [56]. An individualized design of thoracodorsal artery perforator chimeric flap provides a flexible design for customized coverage of complex soft tissue defects with limited donor site morbidity [15]. The technique of two simultaneous pedicled flaps is a simple and successful alternative to free tissue transfer for coverage of complex soft tissue defects in the hand and forearm, particularly in critically ill, multi-extremity injured patients where free tissue transfer is not indicated [31]. Published clinical results for contralateral C7 transfer in stroke or brain-injured patients have demonstrated significant improvements in upper limb function, confirming the procedure's safety and efficacy with typically mild and transient donor site morbidity [55].

Adjuncts: Pelnac® artificial dermis assisted by vacuum sealing drainage can be considered a viable alternative for addressing severe injuries or complex wound conditions [28].

Complications

Wound complications: Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2]. High-pressure water injection injuries should not be underestimated despite an often clinically benign course [65]. Appropriate management of the soft-tissue envelope is essential to a good outcome in high-energy extremity trauma [3]. Open fractures require prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. Management of major and extensive soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training and knowledge rather than limited past experiences [1]. Individualized design of thoracodorsal artery perforator chimeric flaps provides flexible coverage for complex soft tissue defects with limited donor site morbidity [15]. Long-term patient-reported outcome measures and objective outcomes of fingertip coverage with a homodigital unipedicle neurovascular island flap are satisfactory, and the flap is safe and reliable [25]. At 6-month follow-up, patients treated with the homodigital subcutaneous flap for soft tissue coverage of the dorsum of the finger retained robust coverage with no functional restrictions or cold intolerance [30].

Nerve palsy: Injuries to the upper extremities in polytrauma patients have limited effect on long-term outcome provided no injury was caused to the brachial plexus [21]. Rare causes such as soft tissue sarcoma should be considered in cases of compartment syndrome without clear trauma [5].

Other Considerations: A clear understanding of acetabular osseous anatomy and surrounding soft tissues is essential for evaluation and management of acetabular fractures [6]. Evaluation of coxa vara should include a search for family history, trauma, infection, and associated skeletal abnormalities to classify the condition and select optimal treatment [12]. The time elapsed between injury and surgery is not an important risk factor for a good outcome in Zone 2 flexor tendon injuries; outcomes depend on proper surgical methods, surgeon experience, and early mobilization [14]. Long-term outcomes of pelvic fractures are dependent on the pelvic ring injury and associated injuries, complicated by posterior pelvic pain and multifactorial causes [27]. The COVID-19 pandemic and activity restrictions resulted in a decrease in overall hand trauma presentations, particularly elective cases, and alterations in injury type and mechanism [7]. Treatment of benign bony and soft tissue tumors in the hand is often based on small series or experience with similar lesions elsewhere in the body [32]. Early intervention via precise aspiration for metallic mercury injection into soft tissues avoids the need for tissue resection and reconstructive procedures [33].

Recovery

Light activity (weeks): Specific timelines for light activity are not explicitly defined in the provided evidence; however, early mobilization is a critical determinant of outcome in Zone 2 flexor tendon injuries, where the time elapsed between injury and surgery is not an important risk factor for a good outcome [14].

Full activity (months): Most patients achieve maximal recovery by 2 to 3 years following surgical resection for soft-tissue sarcoma of the extremities [69]. Long-term outcomes for pelvic ring injuries are dependent on the injury itself and associated injuries, complicated by posterior pelvic pain and multifactorial influences [27]. Injuries to the upper extremities in polytrauma patients have limited effect on long-term outcome provided no injury was caused to the brachial plexus [21].

Complete recovery / outcome plateau (months): Functional outcomes for Morel-Lavallée lesions in the pediatric population are predominantly achieved through conservative or minimally invasive treatment [22]. Long-term patient-reported outcome measures and objective outcomes for fingertip coverage with a homodigital unipedicle neurovascular island flap are satisfactory, and the flap is safe and reliable [25]. At 6-month follow-up, patients treated with the homodigital subcutaneous flap for soft tissue coverage of the dorsum of the finger retained robust soft tissue coverage with no functional restrictions or cold intolerance [30].

Rehabilitation protocol: Management of major and extensive soft-tissue injuries associated with skeletal fractures requires a planned approach based on broad training and knowledge rather than limited past experiences [1]. Open fractures require prompt antibiotic administration, timely surgical débridement, skeletal stabilization, and soft-tissue coverage [4]. Effective treatment of necrotizing fasciitis relies on prompt diagnosis and immediate, thorough debridement of infected necrotic tissue [9]. Surgical therapy for frostbite of the hand is postponed until there is clear demarcation between healthy and necrotic tissue [71]. Early intervention via precise aspiration for metallic mercury injection into soft tissues avoids the need for tissue resection and reconstructive procedures [33].

Functional milestones: Appropriate management of the soft-tissue envelope is essential to a good outcome, requiring orthopaedic surgeons to adhere to strict principles for accurate decision making and outcome prediction [3]. While most patients with lateral epicondylitis respond to non-operative management, a subset requires operative intervention [26]. Vascularised fibular grafts for reconstruction of extremity bone defects after resection of bone and soft-tissue tumours are associated with a relatively high rate of complications but offer a high rate of successful limb salvage and good long-term functional outcome [58].

Other Considerations: Prevention is the ideal treatment for extravasation injuries, which must be diagnosed and treated promptly to minimize soft tissue injury when they occur [2]. Aeromonas hydrophila should be considered as a causative pathogen when signs of rapidly progressive soft-tissue infection develop in relevant patients [11]. Treatment of benign bony and soft tissue tumors in the hand is often based on small series or experience with similar lesions elsewhere in the body [32]. Further studies with long-term follow-up are needed to determine whether the grafted area in autologous matrix-induced chondrogenesis for focal cartilage defects will maintain structural and functional integrity over time [62].

Key Evidence

  • [L5] Management of major and extensive soft-tissue injuries associated with skeletal fractures requires a planned approach and action based on broad training and knowledge, and not one or two past experiences. (10.2106/00004623-196244040-00018)
  • [L5] Prevention remains the ideal treatment for these iatrogenic injuries, and when they do occur, they must be diagnosed and treated promptly to minimize the amount of soft tissue injury. (10.1016/j.jhsa.2011.10.001)
  • [L5] Appropriate management of the soft-tissue envelope is essential to a good outcome, and orthopaedic surgeons must adhere to strict principles of soft-tissue management to ensure appropriate decision making and accurate prediction of outcome. (10.5435/00124635-199701000-00005)
  • [L4] This case highlights the importance of considering rare causes, like soft tissue sarcoma, in cases of compartment syndrome without clear trauma. (10.1016/j.jhsg.2025.01.003)
  • [L4] The COVID-19 pandemic and consequent restrictions of activity have had substantial impacts on the patterns of hand trauma and its management, resulting in a decrease in overall presentations, particularly elective cases, and alterations in injury type and mechanism. (10.1177/15589447211028918)
  • [L2] The key to effective treatment is prompt diagnosis and immediate and thorough debridement of infected necrotic tissue. (10.1016/j.jhsa.2014.04.010)
  • [L5] Due to the complexity of treatment, any soft-tissue swelling suspected of malignancy is best referred directly to a sarcoma centre. (10.1302/2058-5241.2.170005)
  • [L5] When signs of rapidly progressive soft-tissue infection develop in such a patient, Aeromonas hydrophila should be considered as a causative pathogen. (10.2106/jbjs.c.00923)
  • [L5] Evaluation should include a search for family history, trauma, infection, and associated skeletal abnormalities to classify coxa vara and select optimal treatment. (10.5435/00124635-199803000-00003)
  • [L4] The time elapsed between injury and surgery is not an important risk factor for a good outcome; rather, outcomes depend on proper surgical methods, the surgeon's experience, and early mobilization. (10.1177/17531934211024435)
  • [L4] It provided a flexible design for customized coverage of complex soft tissue defects with limited donor site morbidity. (10.1186/s13018-023-03852-z)
  • [Case_report] The unusual presentation highlights the need to consider this injury when examining the post-traumatic hand. (10.1016/j.jhsa.2007.02.007)
  • [L5] Current evidence regarding the diagnosis of hand compartment syndrome is based mostly on case reports and small case series with varying etiology, lacking a consensus reference standard or reliable diagnostic criteria. (10.1016/j.jhsa.2015.01.034)
  • [L4] Early diagnosis and surgery are critical for treating this sarcoma. (10.1016/j.jhsa.2018.02.020)
  • [L4] This case series demonstrates the extent and severity of hand injuries that can be caused by sword assaults with devastating loss of function for the victims. (10.1177/1753193410381576)
  • [L3] Injuries to the upper extremities seem to have limited effect on long-term outcome in patients with polytrauma, as long as no injury was caused to the brachial plexus. (10.1302/0301-620x.99b2.37999)
  • [L4] Treatment is predominantly conservative or minimally invasive with good functional outcomes. (10.1177/2325967121s00025)
  • [L4] Knowledge of modern repair techniques and rehabilitation protocols may improve patient outcomes. (10.1016/j.jhsa.2014.06.136)
  • [L4] There is insufficient evidence to determine the best splint type or specific indications for surgery. (10.1016/j.jhsa.2009.06.018)
  • [L4] At a long-term follow-up, the patient-reported outcome measures and objective outcomes of this flap are satisfactory and it is a safe and reliable flap. (10.1177/17531934231172081)
  • [L4] This approach can be considered as a viable alternative for addressing severe injuries or complex wound conditions. (10.1186/s13018-025-05547-z)
  • [L5] Minimal, accurate débridement and decompression with early stability are crucial. (10.5435/00124635-201002000-00006)
  • [L4] At 6-month follow-up, all three patients retained robust soft tissue coverage with no functional restrictions or cold intolerance. (10.1007/s11552-010-9279-3)
  • [L4] The technique of two simultaneous pedicled flaps is a simple and successful alternative to free tissue transfer for coverage of complex soft tissue defects in the hand and forearm, particularly in critically ill, multi-extremity injured patients where free tissue transfer is not indicated. (10.1177/1753193409347428)
  • [L5] Treatment of benign bony and soft tissue tumors in the hand is often based on small series or experience with similar lesions elsewhere in the body. (10.1016/j.jhsa.2010.08.015)
  • [L4] The authors share their experience of a successfully treated case of metallic mercury injection into soft tissues by means of precise aspiration, noting that early intervention avoids the need for tissue resection and reconstructive procedures. (10.1177/1753193409344531)
  • [L4] Individuals presenting with SI GSWs are more likely to be older, to require multiple operations, to develop infections, and to present with acute carpal tunnel syndrome requiring urgent surgical decompression. (10.1177/15589447211014603)
  • [L4] A neoplasm should be considered in the differential diagnosis of the cause of a compartment syndrome, as a soft-tissue sarcoma can cause necrosis and edema leading to acute compartment syndrome. (10.2106/00004623-199508000-00017)
  • [L4] Treating providers should recognize crush injury, prolonged decubitus, and infection as the most common causes of acute hand compartment syndrome. (10.1177/15589447221084012)
  • [L5] Improved survival rates on the battlefield have resulted in new and ongoing challenges in the care of U.S. military personnel, necessitating the application of new technology and treatment alternatives to provide the best care to those wounded in war. (10.1016/j.jhsa.2007.07.007)
  • [L4] Despite nonsurgical management and late fasciotomy (> 24 hours) being the most described treatments, the lowest rate of sequelae was observed when decompression was performed within the first 24 hours. (10.1016/j.jhsa.2023.08.013)
  • [L1] Hand trauma, particularly surgical trauma and repetitive mechanical stress, is associated with the onset of Dupuytren's disease. (10.1177/17531934251360545)
  • [L3] Conservative management of tendinous mallet finger injuries that have been neglected for 2 to 4 weeks can be treated as well as those injuries in patients presenting within the first 2 weeks of injury with low long-term complication rates. (10.1016/j.jhsa.2014.06.140)
  • [L4] Closed degloving of the thumb is a rare condition caused by crushing and elongation forces that detaches soft tissues without skin disruption. (10.1016/j.jhsa.2007.06.016)
  • [L5] Common wrist guard design provides limited impact force attenuation, whereas damped pneumatic springs provide substantially enhanced shock-absorbing functions. (10.1177/0363546505281800)
  • [L5] Augmenting plain radiographs with additional imaging modalities like ultrasound or dark-field imaging may aid in diagnosis. (10.1016/j.jhsa.2021.04.004)
  • [L5] Published clinical results have demonstrated significant improvements in upper limb function, confirming the procedure's safety and efficacy, with donor site morbidity that is typically mild and transient. (10.1177/17531934251314640)
  • [L4] Given the current evidence related to management of gunshot wounds to the hand, early debridement, antibiotic treatment, reconstruction, and rehabilitation offer patients the best chance for full functional recovery. (10.1016/j.jhsa.2013.02.011)
  • [L4] Early treatment with debridement and stabilization is recommended, with primary bone grafting considered due to lack of follow-up and patient noncompliance. (10.1177/1558944717697432)
  • [L4] Although associated with a relatively high rate of complications, each reconstruction method is useful, with a high rate of successful limb salvage and a good long-term functional outcome. (10.1302/0301-620x.99b9.bjj-2017-0219.r1)
  • [L4] There are no long-term studies clarifying the natural history or high-quality trials addressing surgical indications and outcomes. (10.1016/j.jhsa.2013.12.027)
  • [L3] Tearing types of injury, such as those caused by saws, led to poorer outcomes for Zone II flexor tendon injuries compared with sharp injuries at an average follow-up of 4 years. (10.1016/j.jhsa.2012.09.021)
  • [L5] Structural repair is performed as indicated by the severity and contamination of the injury, and wounds may require delayed closure. (10.5435/jaaos-23-01-47)
  • [L4] However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time. (10.1007/s00167-010-1042-3)
  • [L4] Management strategies should be based on the depth of tissue involvement, with amputation often necessary when all tissues in the extremity are involved. (10.5435/jaaos-d-24-00125)
  • [L4] The location of the perforator used differs from previous descriptions but is routinely and reliably located. (10.1016/j.jhsa.2021.08.016)
  • [Case_report] Despite an often clinically benign course, high-pressure water injection injuries should not be underestimated. (10.1007/s11552-011-9369-x)
  • [L4] The diagnosis in pediatric cases can be challenging due to presenting symptoms and radiographic findings. (10.1016/j.jhsa.2020.05.002)
  • [L4] However, magnetic resonance imaging indicates that the donor site is resurfaced with fibrous tissue. (10.1177/0363546507306465)
  • [L4] The authors recommend arthrography to assist in deciding whether to proceed with surgical or conservative treatment. (10.1054/jhsb.2001.0656)
  • [L4] Most patients will achieve maximal recovery by 2 to 3 years following surgical resection for soft-tissue sarcoma of the extremities. (10.2106/jbjs.23.01007)
  • [Case_report] Diffusion weighted imaging can effectively identify subcutaneous grease following high-pressure injection injuries, aiding in diagnosis and management. (10.1177/17531934211017401)
  • [L5] Surgical therapy is postponed until there is clear demarcation between healthy and necrotic tissue. (10.1016/j.jhsa.2014.01.035)

See Also

References

[1] Major and Extensive Soft-Tissue Injuries Complicating Skeletal Fractures. The Journal of Bone & Joint Surgery. 1962. DOI: 10.2106/00004623-196244040-00018

[2] Extravasation Injuries. The Journal of Hand Surgery. 2011. DOI: 10.1016/j.jhsa.2011.10.001

[3] Soft-Tissue Injuries Associated With High-Energy Extremity Trauma: Principles of Management. Journal of the American Academy of Orthopaedic Surgeons. 1997. DOI: 10.5435/00124635-199701000-00005

[4] Chapter 14 Evaluation and Management of Soft-Tissue Injury and Open Fractures. 2021.

[5] Forearm Compartment Release with Incidental Soft Tissue Sarcoma. Journal of Hand Surgery Global Online. 2025. DOI: 10.1016/j.jhsg.2025.01.003

[6] Chapter 33 Evaluation and Management of Acetabular Fractures. 2021.

[7] The Impact of COVID-19 on Hand Trauma. HAND. 2021. DOI: 10.1177/15589447211028918

[8] Chapter 8 Acute Compartment Syndrome. 2021.

[9] Necrotizing Fasciitis. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2014.04.010

[10] Diagnosis and treatment of soft-tissue sarcomas of the extremities and trunk. EFORT Open Reviews. 2017. DOI: 10.1302/2058-5241.2.170005

[11] Aeromonas Hydrophila Necrotizing Fasciitis. The Journal of Bone & Joint Surgery. 2006. DOI: 10.2106/jbjs.c.00923

[12] Coxa Vara in Childhood: Evaluation and Management. Journal of the American Academy of Orthopaedic Surgeons. 1998. DOI: 10.5435/00124635-199803000-00003

[13] Chapter 95 Hand Trauma. 2019.

[14] Up to five-week delay in primary repair of Zone 2 flexor tendon injuries: outcomes and complications. Journal of Hand Surgery (European Volume). 2021. DOI: 10.1177/17531934211024435

[15] Individualized design of thoracodorsal artery perforator chimeric flap for customized reconstruction of complex three-dimensional defects in the extremities. Journal of Orthopaedic Surgery and Research. 2023. DOI: 10.1186/s13018-023-03852-z

[16] Sequential Traumatic Bilateral Extensor Pollicis Brevis Rupture: A Case Report. The Journal of Hand Surgery. 2007. DOI: 10.1016/j.jhsa.2007.02.007

[17] Chapter 29 Hand/Carpal Fractures and Dislocations. 2021.

[18] Acute Compartment Syndrome of the Hand. The Journal of Hand Surgery. 2015. DOI: 10.1016/j.jhsa.2015.01.034

[19] Intramuscular Epithelioid Sarcoma Presenting as Extrinsic Flexor Tightness in the Forearm. The Journal of Hand Surgery. 2018. DOI: 10.1016/j.jhsa.2018.02.020

[20] Severe hand injuries resulting from Samurai sword assaults: a Dublin case series. Journal of Hand Surgery (European Volume). 2010. DOI: 10.1177/1753193410381576

[21] Injuries to the upper extremities in polytrauma. The Bone & Joint Journal. 2017. DOI: 10.1302/0301-620x.99b2.37999

[22] ARE SPORTS INJURIES THE MOST COMMON CAUSE OF MOREL-LAVALLEE LESIONS IN THE PEDIATRIC POPULATION?. Orthopaedic Journal of Sports Medicine. 2021. DOI: 10.1177/2325967121s00025

[23] Open Extensor Tendon Injuries. The Journal of Hand Surgery. 2015. DOI: 10.1016/j.jhsa.2014.06.136

[24] Mallet Finger Injuries. The Journal of Hand Surgery. 2009. DOI: 10.1016/j.jhsa.2009.06.018

[25] Long-term patient-reported outcome measures of fingertip coverage with a homodigital unipedicle neurovascular island flap. Journal of Hand Surgery (European Volume). 2023. DOI: 10.1177/17531934231172081

[26] Injuries_Sustained_to_the_Upper_Extremity_Due_to_Modern_Warfare_and_the_Evolutio_S0894113008000690. n.d..

[27] Chapter 32 Pelvic Fractures: Definitive Treatment and Outcomes. 2021.

[28] Pelnac® artificial dermis assisted by vacuum sealing drainage for treatment of severe avulsion injuries of the fingers. Journal of Orthopaedic Surgery and Research. 2025. DOI: 10.1186/s13018-025-05547-z

[29] Early Management of Ballistic Hand Trauma. American Academy of Orthopaedic Surgeon. 2010. DOI: 10.5435/00124635-201002000-00006

[30] The Homodigital Subcutaneous Flap for Soft Tissue Coverage of the Dorsum of the Finger: A Case Series. HAND. 2010. DOI: 10.1007/s11552-010-9279-3

[31] Simultaneous pedicled flaps for coverage of complex blast injuries to the forearm and hand (with supplemental external fixation to the iliac crest for immobilization). Journal of Hand Surgery (European Volume). 2009. DOI: 10.1177/1753193409347428

[32] Benign Bony and Soft Tissue Tumors of the Hand. The Journal of Hand Surgery. 2010. DOI: 10.1016/j.jhsa.2010.08.015

[33] Deliberate self harm with mercury injection in forearm. Journal of Hand Surgery (European Volume). 2010. DOI: 10.1177/1753193409344531

[34] Point Blank: A Retrospective Review of Self-inflicted Gunshot Wounds to the Hand. HAND. 2021. DOI: 10.1177/15589447211014603

[36] Synovial sarcoma presenting as an acute compartment syndrome.. The Journal of Bone & Joint Surgery. 1995. DOI: 10.2106/00004623-199508000-00017

[38] Surgical Demographics of Acute Hand Compartment Syndrome. HAND. 2022. DOI: 10.1177/15589447221084012

[41] Injuries Sustained to the Upper Extremity Due to Modern Warfare and the Evolution of Care. The Journal of Hand Surgery. 2007. DOI: 10.1016/j.jhsa.2007.07.007

[42] Neonatal Limb Compartment Syndrome: A Comprehensive Review. The Journal of Hand Surgery. 2025. DOI: 10.1016/j.jhsa.2023.08.013

[43] Incidence of Dupuytren’s disease following hand trauma: a systematic review. Journal of Hand Surgery (European Volume). 2025. DOI: 10.1177/17531934251360545

[44] Soft-Tissue Mallet Injuries: A Comparison of Early and Delayed Treatment. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2014.06.140

[47] Closed Degloving of the Thumb. The Journal of Hand Surgery. 2007. DOI: 10.1016/j.jhsa.2007.06.016

[49] Chapter 33 Burns and Frostbite. 2019.

[50] Chapter 68 Soft-­Tissue Tumors: Evaluation and Diagnosis. 2020.

[51] Shock Attenuation of Various Protective Devices for Prevention of Fall-Related Injuries of the Forearm/Hand Complex. The American Journal of Sports Medicine. 2006. DOI: 10.1177/0363546505281800

[53] Septic Arthritis of the Proximal Interphalangeal Joint After Rattlesnake Bite. The Journal of Hand Surgery. 2022. DOI: 10.1016/j.jhsa.2021.04.004

[55] Harnessing the uninjured hemisphere for treatment of the stroke or brain-injured patient – evolution of the contralateral C7 transfer. Journal of Hand Surgery (European Volume). 2025. DOI: 10.1177/17531934251314640

[56] Management of Gunshot Wounds to the Hand: A Literature Review. The Journal of Hand Surgery. 2013. DOI: 10.1016/j.jhsa.2013.02.011

[57] Current Trends in the Management of Ballistic Fractures of the Hand and Wrist: Experiences of a High-Volume Level I Trauma Center. HAND. 2017. DOI: 10.1177/1558944717697432

[58] Vascularised fibular grafts for reconstruction of extremity bone defects after resection of bone and soft-tissue tumours. The Bone & Joint Journal. 2017. DOI: 10.1302/0301-620x.99b9.bjj-2017-0219.r1

[59] Rheumatoid Nodules. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2013.12.027

[60] Clinical Outcomes of Zone II Flexor Tendon Repair Depending on Mechanism of Injury. The Journal of Hand Surgery. 2012. DOI: 10.1016/j.jhsa.2012.09.021

[61] Human and Other Mammalian Bite Injuries of the Hand. Journal of the American Academy of Orthopaedic Surgeons. 2015. DOI: 10.5435/jaaos-23-01-47

[62] Mid‐term results of Autologous Matrix‐Induced Chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surgery, Sports Traumatology, Arthroscopy. 2010. DOI: 10.1007/s00167-010-1042-3

[63] Management of Xylazine-Induced Soft-Tissue Necrosis: A Review of 20 Cases. Journal of the American Academy of Orthopaedic Surgeons. 2024. DOI: 10.5435/jaaos-d-24-00125

[64] Reconstruction of Digit Soft Tissue Defects With the Fourth Common Digital Artery Perforator Flap. The Journal of Hand Surgery. 2022. DOI: 10.1016/j.jhsa.2021.08.016

[65] Flexor Tendon Lacerations Due to High-Pressure Water Injection Injury: A Case Report. HAND. 2011. DOI: 10.1007/s11552-011-9369-x

[66] Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion) in Pediatric Phalanges. The Journal of Hand Surgery. 2021. DOI: 10.1016/j.jhsa.2020.05.002

[67] Donor Site Evaluation after Autologous Osteochondral Mosaicplasty for Cartilaginous Lesions of the Elbow Joint. The American Journal of Sports Medicine. 2007. DOI: 10.1177/0363546507306465

[68] Treatment of Soft Tissue Injuries to the Dorsum of the Metacarpophalangeal Joint (Boxer’s Knuckle). Journal of Hand Surgery. 2002. DOI: 10.1054/jhsb.2001.0656

[69] Mapping the Course of Recovery Following Limb-Salvage Surgery for Soft-Tissue Sarcoma of the Extremities. Journal of Bone and Joint Surgery. 2024. DOI: 10.2106/jbjs.23.01007

[70] Diffusion weighted imaging to identify subcutaneous grease after a high-pressure injection injury: a case report. Journal of Hand Surgery (European Volume). 2021. DOI: 10.1177/17531934211017401

[71] Frostbite of the Hand. The Journal of Hand Surgery. 2014. DOI: 10.1016/j.jhsa.2014.01.035

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